Seipin Regulates The Formation Of Nuclear Lipid Droplets From A Distance

Nuclear lipid droplets (nLDs) are poorly characterized outside of the liver. In this issue, Soltysik et al. (2020. J. Cell Biol. https://doi.org/10.1083/jcb.202005026) show that seipin is absent from the nucleus but seipin deficiency promotes nLD formation by increasing nuclear phosphatidic acid.