Hemodynamic Characteristics of Elderly Patients with High Blood Pressure

Objective To study hemodynamic characteristics of elderly patients with high blood pressure. Methods The study selected 94 geriatric patients older than 60 years old in the First Hospital of Shanxi Medical University hospitalized from November 1, 2016 to May 1, 2017. The study included 52 males, 42 females. The basic information were collected including age, sex, weight, and height, and years of hypertension and the level of blood pressure were collected for all hypertensive patients. Non‐invasive hemodynamic monitor records Stroke Volume (SV), Stroke Volume Index (SI), Cardiac Output (CO), Cardiac Output Index (CI), System Vascular Resistance (SVR), Thoracic Fluid Content (TFC) ), Left Ventricular Stroke Work (LSW) and Left Ventricular Stroke Work Index (LSWI), as well as Vascular Elasticity and Contractility Variability. Results According to blood pressure level classification, there was no significant statistical difference among the general clinical data of all subjects such as age, height, weight, body mass index( P >0.05). According to blood pressure levels of hypertensive patients, the hemodynamic parameters had no obvious variability pattern. And with the age increase, SV, SI, CO, CI, vascular elasticity and cardiac contractility variability reduced, SVR increase; and TFC did not change significantly. In addition, LSW and LSWI in elderly hypertensive patients over 80 years of age changed significantly ( P <0.05). According to the level of systolic blood pressure vs diastolic blood pressure, SV, SI, CO, CI, cardiac contractility and other indicators were significantly higher than the control group, and the rest of hemodynamic parameters were not statistically different. As for the high systolic blood pressure group, SV, SI, CO, CI and vascular elasticity are significantly decreased, but SVR, TFC are significantly increased. For both of the high systolic and diastolic blood pressure, LSW and LSWI are significantly increased (P <0.05). Conclusion The use of non‐invasive hemodynamic tests to obtain different hemodynamic parameters may provide a scientific basis for the diagnosis and personalized treatment of hypertensive patients. Support or Funding Information This study was supported by the National Natural Science Foundation Youth Fund (30600637), China Postdoctral Foundation(2014M561207), the Shanxi Province Basic Research Program Youth Science and Technology Research Fund (2010021034‐4, 201601D011119), the Shanxi Scholarship Council of China (2011‐096 and Key Projects No.4), Department of Human Resources and Social Security of Shanxi province, The science and technology research projects of health department of Shanxi Province(2016D011119), The Teaching Reform Program of Shanxi Higher Education, The Education Reform Project of Postgraduate Students in Shanxi Province. The Education Reform Project of Shanxi Medical University. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .