Association between type 2 diabetes mellitus risk factors with breast cancer in Mexican women

Breast cancer is a neoplasic disorder in women worldwide and the comorbidity with type 2 diabetes mellitus (T2DM) is increasing. However, it is not clear how T2DM risk factors such as high waist circumference, hyperglycemia (>100 mg/dL) and dyslipidemia participate in the appearance and development of breast cancer. The aim of this study was to compare T2DM risk factors between women with and without breast cancer. This study included two groups of women 40–60 years old: the control group (n=3) included women with BIRADS 1, 2 and 3 mammograms, and the group with breast cancer (n=3) comprised women in stages I and II of breast cancer. Data were analyzed using Mann‐Whitney test. The results showed that women with breast cancer presented a non‐significant increase ( p =0.40) in the mean concentration of glucose (92.7 ±8.7 mg/dL) compared to the control group (80.0 ±4.3 mg/dL). The mean percentage of glycosylated hemoglobin in women with breast cancer was 5.3 ±0.5 % and the one in the control group was 5.4 ±0.1 %. Additionally, women with breast cancer showed a wider waist circumference (98.7 ±13.2 cm) than the control participants (83.3 ±5.2cm); however, these variables were not significantly different. In summary, there were no significant differences between women with and without breast cancer in the assessed T2DM risk factors; nonetheless, there are clear trends towards altered value limits in these risk factors, therefore, further analyses increasing the sample number are required to confirm the association between T2DM risk factors with breast cancer in this population of women. Support or Funding Information Support provided by Universidad Autónoma del Estado de México. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .