Oxa-Diels-Alder Reaction of Isatins and Acyclic alpha,beta-Unsaturated Methyl Ketones through Cooperative Dienamine and Metal Lewis Acid Catalysis

Lu Liu,Philias Daka,Ryan Sarkisian,Yongming Deng,Kraig Wheeler,Hong Wang

SYNTHESIS-STUTTGART（2014）

引用 10|浏览7

暂无评分

摘要

Cooperative enamine and metal Lewis acid catalysis was applied to develop an asymmetric oxa-Diels-Alder reaction of isatins and but-3-en-2-ones. Spirooxindole tetrahydropyranones were obtained in good yields (58-86%), moderate stereoselectivities (1.3:1-5.9: 1 dr, 50-81% ee), and excellent chemoselectivity.

查看译文

关键词

bifunctional catalysis,tandem reactions,Yb(OTf)(3),oxa-Diels-Alder reaction,spirooxindoles,tetrahydropyranones

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要