Relationships in Gas Chromatography-Fourier Transform Infrared Spectroscopy-Comprehensive and Multilinear Analysis
SEPARATIONS(2020)
摘要
Molecular spectroscopic detection techniques, such as Fourier transform infrared spectroscopy (FTIR), provides additional specificity for isomers where often mass spectrometry (MS) fails, due to similar fragmentation patterns. A hyphenated system of gas chromatography (GC) with FTIR via a light-pipe interface is reported in this study to explore a number of GC-FTIR analytical capabilities. Various compound classes were analyzed-aromatics, essential oils and oximes. Variation in chromatographic peak parameters due to the light-pipe was observed via sequentially-located flame ionization detection data. Unique FTIR spectra were observed for separated mixtures of essential oil isomers having similar mass spectra. Presentation of GCxFTIR allows a 'comprehensive'-style experiment to be developed. This was used to obtain spectroscopic/separation profiles for interconverting oxime species with their individual spectra in the overlap region being displayed on a color contour plot. Partial least square regression provides multivariate quantitative analysis of co-eluting cresol isomers derived from GC-FTIR data. The model resulted in an R-2 of 0.99. Prediction was obtained with R-2 prediction value of 0.88 and RMSEP of 0.57, confirming the method's suitability. This study explores the potential of GC-FTIR hyphenation and re-iterates its value to derive unambiguous and detailed molecular information which is complementary to MS.
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关键词
GC-FTIR,light-pipe interface,isomers,GCxFTIR,oximes,PLSR,spectroscopic detector
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