Using data analytics to accelerate biopharmaceutical process scale-up
Biochemical Engineering Journal(2020)
Abstract
•General framework to accelerate the development cycle of biopharmaceuticals.•Pattern recognition and machine learning to aid process scale-up.•Multiway principal components analysis to identify the most productive and stable cell lines.•Procrustes analysis to assess similarity across scales.•Joint-Y projection to latent structures to predict cell-lines performance across scales.
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Key words
scale-up,scale-down,biopharmaceutical process,data analytics,multivariate statistical techniques,machine learning
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