Steps Forward toward the Substitution of Conventional Solvents in the Heck-Mizoroki Coupling Reaction: Glycerol-Derived Ethers and Deep Eutectic Solvents as Reaction Media

Glycerol-derived ethers and their eutectic mixtures with two renewable ammonium salts (ChCl and N00Cl) are effectively used as new green solvents for the immobilization of PVP-Palladium nanoparticles. Those air-stable, selective, and recoverable catalytic systems are applied in the benchmark Heck-Mizoroki coupling reaction between iodobenzene and n-butyl acrylate in order to evaluate the influence of the different solvation properties of the solvent on the reaction results. The HBD ability (alpha acidity) of the solvent seems to play a crucial role in the reaction selectivity.