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A NEW ACCESS TO 2'-O-ALKYLATED RIBONUCLEOSIDES AND PROPERTIES OF 2'-O-ALKYLATED OLIGORIBONUCLEOTIDES

P Martin

HELVETICA CHIMICA ACTA（1995）

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Abstract
A general access to 2'-O-alkylated ribonucleosides using the key intermediate 5 is presented. The incorporation of 2'-O-'ethyleneglycol'- and 2'-O-'glycerol'-substituted (i.e., 2'-O-(2-hydroxyethyl)- and 2'-O-(2,3-dihydroxypropyl)-substituted) ribonucleosides into oligonucleotides affords a new generation of oligonucleotides with high affinity for RNA, high specificity, and increased nuclease resistance.
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2′-o-alkylated oligoribonucleotides,cheminform abstract
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