Compounds targeting disulfide bond forming enzyme DsbB of Gram-negative bacteria

Cristina Landeta,Jessica L Blazyk,Feras Hatahet,Brian M Meehan,Markus Eser,Alissa Myrick, Ludmila Bronstain,Shoko Minami,Holly Arnold,Na Ke,Eric J Rubin,Barbara C Furie,Bruce Furie,Jon Beckwith,Rachel Dutton,Dana Boyd

NATURE CHEMICAL BIOLOGY（2015）

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摘要

screen for compounds that inhibit disulfide bond formation in β-galactosidase in Escherichia coli found inhibitors of the membrane enzyme DsbB. Given the importance of DsbB in bacterial virulence, the inhibitors are potentially useful as antibacterials.

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