In-vitro Testing of Arsenic Sulfide Nanoparticles for the Treatment of Multiple Myeloma Cells

In this study, alpha- and beta-phase As4S4 nanoparticles were prepared by wet nanomilling using sodium dodecyl sulfate as a surfactant. The properties of the nanoparticles were characterized by particle size distribution and Raman scattering. A monomodal distribution, in the 150 - 200 nm range characterized the particle size of both phases after milling. Raman scattering revealed a common pattern for all studied particles. The existence of pararealgar was documented by Raman spectroscopy. The anticancer effects, of the milled species were confirmed for two multiple myeloma cell lines (RPMI-LR5 and OPM1) in vitro.