New Antibacterial Photoactive Nanocomposite Additives for Endodontic Cements and Fillings

Dentists practice shows, that in the process of treatment of root canal treatment, quite often the secondary infection of canal takes place. This problem, on the one hand, can be caused by inaccurate purification (disinfection) of canals, untight fulfillment of canal, or incidence of bacterial strains (especially anaerobic) in the canals, which are resistant to conventional disinfectants and antiseptics therapy (Sundqvist G, Figdor D, Persson S, Sjogren U Oral Surg Oral Med Oral Pathol Oral Radiol Endod 85:86-93, 1998). In order to solve this problem, we realize the following tasks: (i) from the clinical point collecting of biopsy bacterial strains from root canals of patients, (ii) from the microbiological point identification of bacterial strains, measurement of their microbiological characteristics (which shows, among other, the resistance of bacteria to antibiotics), and carrying out for this strains and the corresponding commercial strains a comprehensive study of the antimicrobial activity of the studied composite materials, (iii) from the physical point identification and explanation the effects of light on antibacterial activity of the composite material, (iv) from the material science point development of canal-filling materials doped with composites, including the measurement of their antimicrobial activity. The final step of investigation should be experimental clinical studies of the developed cements (doped with composites) on biopsy materials.