Extracellular and intracellular zilpaterol and clenbuterol quantification in Hep G2 liver cells by UPLC-PDA and UPLC–MS/MS

Sofia Piña-Olmos,Mariana Dolores-Hernández,Alma Villaseñor,Roberto Díaz-Torres,Efrén Ramírez Bribiesca,Raquel López-Arellano,Patricia Ramírez-Noguera

Journal of Pharmaceutical and Biomedical Analysis（2021）

引用 6|浏览21

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摘要

•To our knowledge this is the first study using a hepatocyte cellular model exposed to Clenbuterol and Zilpaterol.•A complementary methodology was developed using UPLC-PDA for extracellular and UPLC-MS/MS for intracellular quantification.•The analytical methodology was validated and applied to a cellular modeling showing its value for toxicological studies.

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关键词

Clenbuterol,Extracellular compartment,Zilpaterol,Intracellular compartment,UPLC-MS/MS,UPLC-PDA

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