β-Catenin/Lin28/let-7 regulatory network determines type II alveolar epithelial stem cell differentiation phenotypes following thoracic irradiation.

Xiaozhuan Liu,Tingting Zhang,Jianwei Zhou,Ziting Xiao,Yanjun Li,Yuwei Zhang,Haodi Yue,Zhitao Li,Jian Tian

Journal of Radiation Research（2020）

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摘要

The contribution of type II alveolar epithelial stem cells (AEC II) to radiation-induced lung fibrosis (RILF) is largely unknown. Cell differentiation phenotypes are determined by the balance between Lin28 and lethal-7 microRNA (let-7 miRNA). Lin28 is activated by β-catenin. The aim of this study was to track AEC II phenotypes at different phases of injury following thoracic irradiation and examin...

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关键词

type II alveolar stem cells,dynamic differentiation phenotypes,radiation-induced lung fibrosis,transdifferentiation,β-catenin/Lin28/let-7 network

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