Emerging mechanisms to modulate VWF release from endothelial cells
The International Journal of Biochemistry & Cell Biology(2021)
摘要
Agonist-mediated exocytosis of Weibel-Palade bodies underpins the endothelium’s ability to respond to injury or infection. Much of this important response is mediated by the major constituent of Weibel-Palade bodies: the ultra-large glycoprotein von Willebrand factor. Upon regulated WPB exocytosis, von Willebrand factor multimers unfurl into long, platelet-catching ‘strings’ which instigate the pro-haemostatic response. Accordingly, excessive levels of VWF are associated with thrombotic pathologies, including myocardial infarction and ischaemic stroke.
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关键词
ADAMTS13,aTTP,AP-1,CVD,COPI,COPII,cTTP,cAMP,ER,EC,GBF1,HUVEC,IL-8,KLF2,MRP-1,MI,MARCKS,NSF,MyoII,PKA,PKC,SNARE,TGN,FDA,VEGFR2,Sec22b,VWD,VWF,WPB
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