Paeoniflorin ameliorates experimental colitis by inhibiting gram-positive bacteria-dependent MDP-NOD2 pathway

Xia Luo, Xiaojing Wang,Shaowei Huang,Bo Xu,Shuang Luo,Yanyang Li,Qing Wang,Yanping Chen,Xiangliang Deng,Lingyun Liu,Lian Zhou

International Immunopharmacology（2021）

Cited 20|Views18

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Abstract

•The abundance of Gram-positive increased in UC mice.•Gram-positive bacteria induced intestinal inflammation through MDP-NOD2 signaling pathway.•Paeoniflorin reduced the abundance of Gram-positive bacteria in UC mice.•Paeoniflorin is able to inhibit Gram-positive bacteria-dependent MDP-NOD2 pathway to alleviate mice colitis.

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Key words

Dextran sodium sulfate,Inflammatory bowel disease,Muramyl dipeptide,NF-κB,Tumor necrosis factor-α,Ulcerative colitis

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