High-throughput and wide-range simultaneous determination of linezolid, daptomycin and tedizolid in human plasma using ultra-performance liquid chromatography coupled to tandem mass spectrometry
Journal of Pharmaceutical and Biomedical Analysis(2021)
Abstract
•The first simultaneous quantification method for linezolid, daptomycin and tedizolid in human plasma is reported.•The high-throughput assay has short pretreatment and run time, with wide-range calibration curves capable of measuring both Cmax and Ctrough.•The assay fulfilled the requirements of US Food and Drug Administration and the European Medicines Agency for bioanalytical method validation.
MoreTranslated text
Key words
Linezolid,Daptomycin,Tedizolid,Ultra-performance liquid chromatography coupled to tandem mass spectrometry,Intensive care unit,Therapeutic drug monitoring
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined