Cannabidiol reduces soman-induced lethality and seizure severity in female plasma carboxylesterase knockout mice treated with midazolam

•Cannabidiol pre-treatment reduces lethality to soman exposure in female Es1-/- mice.•Cannabidiol reduces soman-induced seizure severity in midazolam-treated female mice.•Cannabidiol reduces soman-induced weight loss in midazolam-treated female mice.•Cannabidiol may augment the effects of midazolam in mitigating soman-induced toxicity.