Therapeutic potential of natural products against atherosclerosis: Targeting on gut microbiota

Xin Zhao,Patrick Kwabena Oduro,Wanyu Tong,Yuefei Wang,Xiumei Gao,Qilong Wang

Pharmacological Research（2021）

Cited 0|Views7

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Abstract

•Distortion of gut microbiota accelerates atherosclerosis via dysregulation of lipid metabolism, inflammation, and endothelial dysfunction.•Gut microbiota dependent metabolites regulate atherogenesis.•Gut microbiota-origin probiotic influences atherosclerosis pathobiology.•Natural products promote beneficial gut bacteria phylotypes and anti-atherogenic metabolites.•Natural products exert additional cardioprotective properties against atherosclerosis.

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Key words

ABCA1,ABCG,A-FABP,ApoE−/−,AS,BBR,CVDs,Cyp27A1,eNOS,FMOs,FXR,GLP-1,GM,GPCR,HDL,HFD,HMGCR,HUVECs,ICAM-1,IL,LDL,LPS,LXR,miRNA,NF-κB,NLRP3,NO,NPC1L1,Ox-LDL,PMFs,PPAR,RCT,ROS,SCFAs,SIRT,SOD,SREBP,TC,TG,TLR,TMA,TMAO,TNFα,TSG,VCAM-1

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