Tenofovir Alafenamide Attenuates Effects of Diabetes and Body Mass on Serum Alanine Aminotransferase Activities in Patients With Chronic Hepatitis B

Pimsiri Sripongpun,W Ray Kim,Ajitha Mannalithara,Allison Kwong,Tami Daugherty,Aparna Goel,Paul Y Kwo

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY（2022）

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摘要

Persistent serum alanine aminotransferase (ALT) elevation in nucleotide/nucleoside analogue (NA)-treated patients with chronic hepatitis B (CHB) has been associated with unfavorable long-term outcomes. It has been consistently shown that a higher proportion of patients receiving tenofovir alafenamide (TAF) achieve normal ALT in comparison with recipients of tenofovir disoproxil fumarate, the mechanism for which remains unknown..

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MAFLD,hepatitis B virus,metabolic-associated fatty liver disease,non-alcoholic fatty liver disease,nucleotide analogs,switch,treatment outcome

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