Inherited Chromosomally Integrated Human Herpesvirus 6: An Unexpected Finding in a Septic Neonate
PEDIATRIC INFECTIOUS DISEASE JOURNAL(2021)
Abstract
Human herpesvirus 6 (HHV-6) can integrate its genome in human chromosomes and be germline transmitted (inherited chromosomally integrated HHV-6). We report a case of chromosomally integrated HHV-6 inherited from the mother unexpectedly diagnosed in a septic neonate. Since HHV-6 has recently been included in multiplex polymerase chain reaction assays for meningitis/encephalitis, diagnosing inherited chromosomally integrated HHV-6 status is essential to avoid misdiagnosis of active HHV-6 infection and unnecessary antiviral treatment.
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Key words
human herpesvirus 6,HHV-6,inherited herpesvirus,chromosomal integration,neonatal sepsis
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