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Distinct maternal amino acids and oxylipins predict infant fat mass and fat-free mass indices

Monika Riederer, Marlies Wallner, Natascha Schweighofer, Bianca Fuchs-Neuhold, Anna Rath, Andrea Berghold, Katharina Eberhard, Andrea Groselj-Strele, Wolfgang Staubmann, Marie Peterseil, Irmgard Waldner, Johannes A. Mayr, Michael Rothe, Sandra Holasek, Susanne Maunz, Elisabeth Pail, Moenie van der Kleyn

Archives of physiology and biochemistry(2023)

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摘要
Interested in maternal determinants of infant fat mass index (FMI) and fat-free mass index (FFMI), considered as predictors for later development of obesity, we analysed amino acids (AA) and oxylipins in maternal serum and breast milk (BM). FMI and FFMI were calculated in 47 term infants aged 4 months (T4). Serum AA were analysed in pregnancy (T1, T2) and 6-8 weeks postpartum (T3). At T3, AA and oxylipins were analysed in BM. Biomarker-index-associations were identified by regression analysis. Infant FMI (4.1 +/- 1.31 kg/m(2); MW +/- SD) was predicted by T2 proline (R (2) adj.: 7.6%, p = .036) and T3 BM 11-hydroxy-eicosatetraenoic-acid (11-HETE) and 13-hydroxy-docosahexaenoic-acid (13-HDHA; together:35.5% R (2) adj., p < .001). Maternal peripartum antibiotics (AB) emerged as confounders (+AB: 23.5% higher FMI; p = .025). Infant FFMI (12.1 +/- 1.19 kg/m(2); MW +/- SD) was predicted by histidine (R (2) adj.: 14.5%, p < .001) and 17-HDHA (BM, R (2) adj.:19.3%, p < .001), determined at T3. Confirmed in a larger cohort, the parameters could elucidate connections between maternal metabolic status, nutrition, and infant body development.
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关键词
Infant body composition,oxylipins,amino acids,fat mass index,maternal biomarkers
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