Epigenome-wide associations between observed maternal sensitivity and offspring DNA methylation: a population-based prospective study in children.

Lorenza Dall' Aglio,Jolien Rijlaarsdam,Rosa H Mulder,Alexander Neumann,Janine F Felix,Rianne Kok,Marian J Bakermans-Kranenburg,Marinus H van Ijzendoorn,Henning Tiemeier,Charlotte A M Cecil

Psychological medicine（2022）

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摘要

These findings provide novel leads into the relationship between typical variation in maternal caregiving and offspring DNAm in humans, highlighting robust regions of associations, previously implicated in psychological and developmental problems, immune functioning, and stress responses.

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关键词

Caregiving environment,DNA methylation,EWAS,child development,epigenetics,mQTLs,maternal care,maternal sensitivity,population-based sample

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