Prenatal Exposure To Preeclampsia As A Risk Factor For Long-Term Endocrine Morbidity Of The Offspring

Objective: To analyze preeclampsia as a risk factor for pediatric endocrine disease.Study Design: A population-based cohort analysis comparing the risk of endocrine morbidity of children born between 1991-2014 to mothers with and without preeclampsia.Results: The study included 253,808 deliveries. Exposed offspring had significantly more endocrine hospitalizations (0.7% vs 0.4%; p < 0.001), specifically obesity (0.4% vs 0.2%, p < 0.001). While controlling for confounders, the exposed offspring had significantly more endocrine morbidity (OR 1.433 95% CI 1.115-1.841 p = 0.005).Conclusion: Preeclampsia is an independent risk factor for long-term endocrine disease of the offspring, specifically obesity.