Design, Synthesis and Biological Evaluation of N-glycosy-4-(coumarin-3-yl)-1, 3-thiazole-2-amines as Acetylcholinesterase Inhibitors

A new series ofN-glycosy-4-(cotunarin-3-yl)-1, 3-thiazole-2-amines were synthesized in high yield, characterized and biologically evaluated for their acetylcholinesterase (AChE) inhibition activities. All compounds showed different degrees of inhibition on AChE. Among them, compound 11c showed the best AChE inhibition rate and was found to be the most potent inhibitor of AChE. [GRAPHICS] .