Synthesis of N-alpha-Z protected amino alkyl triazole acids and their application to neo-glycopeptides synthesis
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY(2014)
摘要
The synthesis of triazole linked glycopeptides employing 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) mediated coupling of Z-protected triazole acids with glycosyl amines and amino acid esters is described. The coupling proceeded smoothly at room temperature and the products are obtained in good yields. Z-Protected triazole acids have been synthesized via click chemistry protocol through the cycloaddition of Z-protected alkyl azides with propiolic acid.
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关键词
Triazole,CDMT,neoglycopeptides,click reaction
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