Regio- and stereoselective C(sp(2))-H acylation of enamides with aldehydesviatransition-metal-free photoredox catalysis

A straightforward and efficient C(sp(2))-H acylation of enamides with aldehydesviatransition-metal-free photoredox catalysis is demonstrated. The transformation proceeded smoothly without resorting to expensive and potentially toxic iridium or ruthenium polypyridyl-based photocatalysts under mild conditions, furnishing a diverse range of synthetically crucial, geometrically defined beta-acylated enamides in a stereoselective and regioselective manner.