NANOCOMPOSITE OF Ag(0)NPs SUPPORTED ON SIO2 MICROSPHERES INDUCES WOUND HEALING IN EXPERIMENTAL SKIN INCISIONS
DIGEST JOURNAL OF NANOMATERIALS AND BIOSTRUCTURES(2018)
Abstract
We investigated the influence of coverage the surface of silica microspheres with silver nanoparticles (Ag-0 NPs) in to skin wound healing. We prepared silica microspheres, either pristine or doped with Ag-0 NPs that were created after the hydrolysis/condensation of tetraethoxysilane, according to Stober methodology; these substrates were characterized through spectroscopic and microscopic techniques. The wound healing activity was tested and monitored on male Wistar rats (n=15) during 12 days. Finally, a skin biopsy samples were analyzed through hematoxylin-eosin and Masson-trichrome stainings or by immune histochemical localization of fibroblastic and proliferative cells markers. Silica microspheres of 300 nm in size, carrying Ag-0 NPs of about 1.6-3 nm were synthesized and employed for skin tissue repairing. The animals that received treatment with pristine or Ag-doped silica nanosystems showed similar recovery patterns; nevertheless, the animals treated with Ag doped microspheres exhibited additional features such as an enlarged presence of hair follicles, insignificant inflammatory infiltrate and an epithelial thickness of a lesser extent. Similarly, in the same group an important presence of blood microvessels, fibloblast and proliferating cells were observed. These results suggest that silica microspheres coated with Ag-0 NPs induce significantly better skin wound reparation effects through the modulation of angiogenic, inflammatory, fibrogenic, and proliferative mechanisms.
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Key words
Wound healing,Ag-nanoparticles,SiO2-microspheres,Inflammation,Angiogenesis
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