White Matter Lesions In Multiple Sclerosis Are Enriched For Cd20(Dim) Cd8(+) Tissue-Resident Memory T Cells

Cheng-Chih Hsiao,Nina L. Fransen,Aletta M. R. Van Den Bosch,Kim I. M. Brandwijk,Inge Huitinga,Jorg Hamann,Joost Smolders

MULTIPLE SCLEROSIS JOURNAL（2021）

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摘要

Brain CD8 CD69 tissue-resident memory T (T ) cells comprise a CD20 subset, which is proportionally larger in CD103-negative T cells. In multiple sclerosis (MS) lesions, CD20 T -cell proportions are increased. CD20-expression is associated with higher levels of CXCR6, Ki-67, and granzyme B, supporting CD20 T cells as a relevant subset in MS.

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关键词

brain, CD20, human, multiple sclerosis, tissue-resident memory T cells

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