Composite Particles Gel - Alg - Apatite for Bone Tissue Regeneration

This paper reports the fabrication of spherical particles developed as bone tissue regenerative biomaterials. Inspired by the extracellular matrix of hard tissues, the particles were generated through the mineral loading of a macromolecular matrix consisting in a bicomponent hydrogel (interpenetrated polymer networks based on gelatin and alginate). The study describes the effects of the peptide-polysaccharide ratio on the morpho-structural features, water affinity, and interaction with MG-63 osteoblast-like cells.