Generation and Characterization of Abt-981, A Dual Variable Domain Immunoglobulin (Dvd-Ig(tm)) Molecule That Specifically and Potently Neutralizes Both Il-1 Alpha and Il-1 Beta
MABS（2015）
Key words
ADA, Anti-drug antibodies,CDR, complementarity-determining region,CEC, cation exchange chromatography,Cyno, cynomolgus monkey,DVD-Ig, dual variable domain immunoglobulin,ED50, efficacious dose at 50% response,ED80, efficacious dose at 80% response,ELISA, enzyme-linked immunosorbent assay,IL-1, interleukin-1,IgG1, immunoglobulin G1,IV, intravenous,OA, osteoarthritis,PAS, protein A sepharose,SC, subcutaneous,SEC, size exclusion chromatography,SPR, surface plasmon resonance,V-H, antibody heavy chain variable domain,V-L, antibody light chain variable domain
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