Synthesis, Anti-tumor Activity and Odd-even Effect of Simple Isatin Derivatives
LETTERS IN DRUG DESIGN & DISCOVERY(2015)
Abstract
In this work, a series of N-substituted isatin derivatives was synthesized by different reactions. The synthesized isatin derivatives were characterized by NMR, MS and elemental analysis. Then the anti-tumor activities of these compounds were evaluated through the cytotoxicity against A549 and P388 cell line test. The results show that several compounds show much higher anti-tumor activity than that of isatin, and there is an even-odd effect in the structure activity relationship.
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Key words
Isatin,derivative,synthesis,anti-tumor,neuro-protection,even-odd effect
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