Clinicopathologic Features of Peripheral T-Cell Lymphoma in Sub-Saharan Africa

Objectives: Peripheral T-cell lymphomas (PTCLs) are heterogeneous, clinically aggressive, and rare. Subtype distribution varies by geographic location; however, data from sub-Saharan Africa (SSA) are lacking. We sought to elucidate clinicopathologic features of PTCL in SSA. Methods: We reviewed PTCL consultation cases from three SSA countries. PTCL subtype was determined per 2017 World Health Organization classification. Cases with sufficient material were evaluated by polymerase chain reaction for human T-cell leukemia virus type 1 (HTLV-1) and T-cell receptor gamma (TCRG) rearrangement. Results: Among 32 cases; median age was 45 years and male-to-female ratio was 1.7. Thirty ( 94%) of 32 cases required additional workup for subclassification. PTCL, not otherwise specified ( PTCL-NOS) was the most common subtype ( 13/32, 41%), followed by PTCL with T-follicular helper phenotype (6/32, 19%) and systemic anaplastic large cell lymphoma (6/32, 19%). Four ( 16%) of 25 cases were Epstein-Barr virus positive (EBV+) (2/2 extranodal natural killerlT-cell lymphoma, 1/13 PTCL-NOS, and 1/4 angioimmunoblastic T-cell lymphoma with EBV+ immunoblasts). Two (15%) of 13 patients with PTCL-NOS were human immunodeficiency virus positive. No cases with evaluable DNA (0/15) were HTLV-1 positive, and 9 of 10 showed clonal TCRG rearrangements. Conclusions: In comparison to Western studies PTCLs from SSA show similar subtype distribution and male predominance but a younger age at diagnosis Appropriate diagnosis of PTCL, requires extensive ancillary testing not readily available in low-income cowries including much of SSA.