Antigen presentation genes in gadoid species (haddock: Melanogrammus aeglefinus and Atlantic cod: Gadus morhua) raise questions about cross-presentation pathways and glycosylated beta-2-microglobulin

Aaron Frenette,Marije Booman,Kazuhiro Fujiki,Stephen Kales, Collen Ryan,A Kurt Gamperl,Brian Dixon

Molecular Immunology（2021）

Cited 3|Views14

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Abstract

•Haddock express multiple classical and non-classical MHC-I molecules.•Haddock MHC-I molecules lack endosomal sorting signals involved in cross-presentation.•De-glycosylation trials reveal Atlantic cod and haddock β2 M are N-linked glycosylated.•β2M glycosylation sites appear frequently within Gadiformes and Perciformes lineages.

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Key words

Atlantic cod,Haddock,Major histocompatibility class I,Endosomal sorting signals,Cross-presentation,Beta-2-microglobulin,Polyclonal antibodies,Glycosylation

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