Detergent‐Like Polymerizable Monomers: Synthesis, Physicochemical, and Biochemical Characterization
European Journal of Organic Chemistry(2020)
Abstract
Three monomers with a maltose polar head, an alkyl hydrogenated chain, and an acrylamide-based polymerizable moiety were synthesized. The self-assembly properties in aqueous solutions of these monomers were studied by means of isothermal titration calorimetry (ITC), surface tension (SFT) measurements, and dynamic light scattering (DLS), which indicated the formation of small micellar aggregates of about 6 nm diameter. The critical micellar concentration (CMC) was found to depend on the length of the alkyl chain and on the nature of the polymerizable moiety, ranging from 0.35 mmto ca. 10 mm. The monomers were found to solubilize phospholipid vesicles and to extract a broad range of proteins fromEscherichia colimembranes. Finally, the extraction of two membrane proteins, namely, the full-length, wild-type human G-protein-coupled receptor (GPCR) adenosine A2A receptor (A(2A)R) and the bacterial transporter AcrB was demonstrated.
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Key words
Detergents,Monomers,Surfmers,Extraction,Membrane proteins
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