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Genome-Wide Association Study Identifies Two Novel Loci Associated with Female Stress and Urgency Urinary Incontinence

Rufus Cartwright,Larissa Franklin,Kari A O Tikkinen,Ilkka Kalliala,Pawel Miotla,Tomasz Rechberger,Ifeoma Offiah,Steve McMahon,Barry O'Reilly,Sabrina Lince,Kirsten Kluivers,Wilke Post,Geert Poelmans,Melody R Palmer,Hunter Wessels,Andrew Wong,Diana Kuh,Mika Kivimaki,Meena Kumari,Massimo Mangino,Tim Spector,Jeremy A Guggenheim,Benjamin Lehne,N Maneka G De Silva,David M Evans,Debbie Lawlor,Ville Karhunen,Minna Mannikko,Malgorzata Marczak,Phillip R Bennett,Vik Khullar, Marjo-Riitta Järvelin,Andrew Walley

EUROPEAN JOURNAL OF HUMAN GENETICS（2021）

Cited 5|Views17
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Abstract
We uncovered two new risk loci near the genes Endothelin 1 (), associated with urgency incontinence and Macrophage Receptor with Collagenous Structure (), associated with stress incontinence. These loci are biologically plausible given their roles in smooth muscle contraction and innate host defense respectively.
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Key words
ALSPAC,genetics,genome-wide association study,genomics,stress urinary incontinence,urgency urinary incontinence
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