Evaluation of Fetuin-A level and related factors in obese adolescents
HORMONE RESEARCH IN PAEDIATRICS(2019)
摘要
Abstract Inflammation is thought to be responsible for insülin resistance and fatty liver in obese cases. The contribution of fetuin-A the inflammation process is not clear. We aimed to evaluate fetuin-A levels in obese adolescents and to evaluate its relationship with anthropometric data, insulin levels and high-sensitive CRP. We found that there was no difference in fetuin-A levels between obese and healthy cases in the whole group. However, hs-CRP levels of obese patients were found to be significantly higher than healthy subjects. There was no difference in terms of fetuin-A and hs-CRP levels between the insulin-resistance and non-resistance group. There was no correlation between lipid parameters and fetuin-A levels. There was no difference in terms of fetuin-A and hs-CRP in cases with and without fatty liver. This may suggest that although systemic inflammation starts in obese patients, fetuin-A is not involved in this process or that the negative effect of fetuin-A on inflammation with other factors is still balanced in the adolescent age group. As a conclusion, further studies are needed to evaluate at what stage and how fetuin-A participates in systemic inflammation physiopathologically.
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