Effect of Sofosbuvir/Ledipasvir and Glecaprevir/Pibrentasvir on Serum Creatinine.

Waseem Amjad,Talan Zhang,Anurag Maheshwari,Paul J Thuluvath

HEPATOLOGY（2022）

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摘要

Treatment of chronic hepatitis C infection with both SOF/LDV and GLE/PIB regimens may result in an increase of creatinine, and 6-7% will have an increase in serum creatinine of ≥0.3 mg/dL. The increase in creatinine, however, is unrelated to the type of DAA combination.

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关键词

AKI, acute kidney injury,Cr, creatinine,DAA,DAA, direct acting antivirals,GFR, glomerular filtration rate,GLE/PIB, glecaprevir/pibrentasvir,HAART, highly active antiretroviral therapy,HCV, hepatitis C,IFN, interferon,SOF/LDV, sofosbuvir/ledipasvir,SVR, sustained virological response,TLV/BOC, telaprevir/boceprevir,direct antiviral agents,hepatitis C infection: serum creatinine

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