New Minimally Invasive and Tailor-Made Strategy for Cryoballoon Ablation in Patients With Paroxysmal Atrial Fibrillation
Heart, Lung and Circulation(2022)
摘要
Background
The optimal dosage for cryoballoon ablation (CBA) of atrial fibrillation (AF) is still unknown.
Objective
This study aimed to evaluate the clinical implications of a reduction in the freezing duration to <180 seconds during CBA guided by the time to the target temperature.
Methods
This study enrolled 325 consecutive paroxysmal AF patients who underwent CBA. It was a retrospective observational study in a single centre. It compared 164 patients who underwent a tailor-made CBA procedure (group T) with 161 who had a standard CBA procedure (group S). In group T, the freezing duration was reduced to 150 seconds when the temperature reached ≤ –40 °C within 40 seconds. Furthermore, it was reduced to 120 seconds when it reached ≤ –50 °C within 60 seconds. In the other patients, the freezing duration was 180 seconds, except for excessive freezing of ≤ –60 °C and/or emergent situations while monitoring the oesophageal temperature, and for phrenic nerve injury, as in group S.
Results
In group T, 89 patients (83%) underwent CBA with a reduction in the freezing duration. The total freezing time for each pulmonary vein was significantly shorter in group T than group S, and the total procedure time in group T decreased by an average of 4 minutes compared with group S. The rate of requiring additional radio frequency ablation following the CBA was significantly lower in group T than group S. The AF-free survival rate during the follow-up period (median, 366 days) was similar between the two groups.
Conclusion
The safety and efficacy of the new CBA strategy were non-inferior to the standard procedure.
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关键词
Cryoballoon ablation,Atrial fibrillation,Freezing duration,Pulmonary vein isolation,Time to target temperature
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