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MODEL-BASED MINIMUM ANTICIPATED BIOLOGICAL EFFECT LEVEL (MABEL) APPROACH LED TO SAFE HUMAN STARTING DOSE OF THREE DOMAIN ANTIBODIES FOR AUTOIMMUNE DISEASES.

R. Shi,H. Wang,S. Suchard,S. Nadler,M. Honczarenko,S. Zhang, T. Salcedo,K. Price,C. Fleener,B. Ganguly,J. Mora, J. Haulenbeek, R. Liu,B. Murthy,Z. Yang

CLINICAL PHARMACOLOGY & THERAPEUTICS（2015）

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