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Pluripotent Stem Cellderived Cardiomyocytes From a Patient With Arg723gly beta-myosin Heavy Chain Mutation Show Alterations in Twitch Contractions, Calcium Transients and Highly Variable Allele Specific Expression of Mutant/wildtype beta-myosin Heavy Chain Mrna

Natalie Weber,Tim Holler,Joachim Meissner,Judith Montag,Neele Peschel, Anne Kathrin Mayer,Kristin Schwanke,Birgit Piep,Ulrich Martin,Robert Zweigerdt,Theresia Kraft

CIRCULATION（2019）

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Abstract
Hypertrophic cardiomyopathy (HCM) is the most frequent inherited cardiac disease. In mutation-positive patients one third of the mutations are located in the β-cardiac myosin heavy chain protein (β...
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cardiomyocytes,mrna,twitch contractions,cell-derived
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