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Intramolecular Inhibition of Ser473 Phosphorylation by Up-regulated Thr308 Phosphorylation in Akt Contributes to Enlargement of Infarct Size by Chronic Renal Failure

Toshiyuki Tobisawa,Toshiyuki Yano,Takayuki Miki,Masaya Tanno,Atushi Kuno,Hidemichi Kouzu,Makoto Ogasawara,Shingo Muratsubaki,Kohei Ohno,Keitaro Nishizawa,Masashi Mizuno,Wataru Ohwada,Satoko Ishikawa,Tetsuji Miura

CIRCULATION（2015）

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Abstract
Objective: We previously showed that chronic renal failure (CRF) enlarges infarct size after ischemia/reperfusion (I/R) through impairment of reperfusion-induced Akt activation. Here we examined mo...
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Key words
CKD,myocardial infarct,cardio-renal syndrome
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