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Effects of Protease Activated Receptor-1 Signaling Inhibition on Cardiac Hypertrophy and Fibrosis in Renin Overexpressing Hypertensive Mice

Yoshikazu Yokono,Masato Narita, Yousuke Kawamura,Tomo Kato,Natsumi Kudo,Michiko Tsushima,Yuichi Toyama,Kenji Hanada,Michiko Shimada,Tomohiro Osanai,Hirofumi Tomita

CIRCULATION（2019）

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Abstract
Introduction: Protease activated receptor-1 (PAR-1) is widely expressed in the vasculature and the heart, and plays important roles in the progression of cardiovascular disease. Recent studies show...
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renin overexpressing hypertensive mice,cardiac hypertrophy,protease,fibrosis
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