Synthesis, Crystal Structure and Biological Activity of (2,4-Dihydroxy-3,6-ditnethoxyphenyl)-((1R,2S,3S,4R,7R)-7-isopropyl-5-tnethyl-3-phenylbicyclo[2.2.2]-oct-5-en-2-yl)methanone
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY(2018)
Abstract
The crystal structure of the natural terpene derivative (2,4-dihydroxy-3,6-dimethoxyphenyl)((1R,2S,3S,4R,7R)-7-isopropyl-5-methyl-3-phenylbicyclo [2.2.2]oct-5-en-2-yl)-methanone was determined by single-crystal X-ray diffraction method. The compound crystallizes in triclinic, space group P2(1)/c with a = 16.1444(9), b = 16.5294(9), c = 19.7875(11) angstrom, V= 5280.4(5) angstrom(3) , Z = 4, D-c = 1.209 g/cm(3), F(000) = 2064, mu(CuK alpha) = 0.675 mm(-1), S = 1.069, R = 0.0520 and wR (I> 2 sigma(I)) = 0.1392. The spiro structure constructed by Diels-Alder reaction was highly symmetric. In addition, the title compound showed inhibitory activities against cancer cell line with varied potencies.
MoreTranslated text
Key words
monoterpene,total synthesis,crystal structure,biological activity
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined