Synthesis, Crystal Structure and Biological Activity of (2,4-Dihydroxy-3,6-ditnethoxyphenyl)-((1R,2S,3S,4R,7R)-7-isopropyl-5-tnethyl-3-phenylbicyclo[2.2.2]-oct-5-en-2-yl)methanone

The crystal structure of the natural terpene derivative (2,4-dihydroxy-3,6-dimethoxyphenyl)((1R,2S,3S,4R,7R)-7-isopropyl-5-methyl-3-phenylbicyclo [2.2.2]oct-5-en-2-yl)-methanone was determined by single-crystal X-ray diffraction method. The compound crystallizes in triclinic, space group P2(1)/c with a = 16.1444(9), b = 16.5294(9), c = 19.7875(11) angstrom, V= 5280.4(5) angstrom(3) , Z = 4, D-c = 1.209 g/cm(3), F(000) = 2064, mu(CuK alpha) = 0.675 mm(-1), S = 1.069, R = 0.0520 and wR (I> 2 sigma(I)) = 0.1392. The spiro structure constructed by Diels-Alder reaction was highly symmetric. In addition, the title compound showed inhibitory activities against cancer cell line with varied potencies.