Microwave-Assisted Rapid Regioselective One-Pot Synthesis of Novel 2-Oxothiazolidine Dicarboxylate

Vikas Madhukar Bangade,Prakash Rambhau Mali, Prashishkumar Kishan Shirsat,Harshadas Mitaram Meshram

CHEMISTRYSELECT（2019）

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Abstract

A regioselective synthesis of 2-oxothiazolidine dicarboxylate (OTDC) under microwave irradiations is reported. Methoxylation, demethylation and double reductive cyclization occurs in single step by three component one pot reaction under microwave irradiations. The microwave irradiations, planar arrangement of intermediate imino(sp2)-thio-maleate and in situ demethylation considered as driving forces for regioselective cyclization.

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Key words

Double reductive cyclization,Microwave chemistry,Multicomponent reactions,2-Oxothiazolidine dicarboxylate (2-OTDC),Regioselectivity

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