Catalyst-Free alpha-Aminoxylation of 1,3-Dicarbonyl Compounds with TEMPO Using Selectfluor as an Oxidant

A catalyst-free and regioselective alpha-aminoxylation of 1,3-dicarbonyl compounds with TEMPO by use of Selectfluor as a mild oxidant has been demonstrated, yielding the corresponding alkoxyamines in good to excellent yields. The developed protocol features no employment of a catalyst, broad substrate scope and mild reaction conditions, which enables a convenient and efficient avenue for quaternary C-O bond formation.