Synthesis and Characterization of a New Class of Triazoles Containing Bicyclic Silaheterocycles
CHEMISTRYSELECT(2017)
Abstract
A new class of bicyclic silaheterocycles, 6,6-dimethyl-2-aryl-6,7-dihydro- 5H-[1,2,4] triazolo[5,1-b][1,3,5] thiazasilines, which could be developed as potential sila-drugs. The reactions of several 3-aryl- 5-mercapto-1,2,4-triazoles with bis(chloromethyl) dimethylsilane under basic conditions gave high yields of bicyclic products. Reaction, product workup and isolation were streamlined without requiring an anhydrous solvent, inert gas or chromatographic purification. The products were structurally characterized by single-crystal X-ray diffraction.
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Key words
Cyclization,Nitrogen heterocycles,Silaheterocycle,Silicon,Triazole
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