A New Class of Boronic Acid-Derived Amphiphile-Based Gel Emulsions Capable of Entrapping and Releasing Vitamin B-12 and Doxorubicin

In this work, two boronic acid based amphiphiles, Sodium salt of 2-amidodecylpyridine-5-boronic acid (SADPB) and Sodium salt of 2-amidododecylpyridine-5-boronic acid (SADDPB) have been synthesized and their gel-emulsion property in organic solvents were investigated. The good gelation ability of the amphiphiles was confirmed by low minimum gelation concentration (MGC) and high gelation number (N-gel) values. Theoretical study established that introduction of amide linkage in the amphiphilic structure dismantles aggregate formation. The gel-emulsions are stable towards mechanical and thermal responses. The gelation process is also dependent on the nature of solvent and type of amphiphiles. The morphology of gel-emulsions is highly dependent on the concentration of the amphiphile. The prepared gel-emulsions are able to encapsulate and release biomolecule vitamin B-12 and anticancer drug doxorubicin at room temperature. Both vitamin B-12 and doxorubicin exhibited retention of their structures and activity which has been recognized this new type of boronic acid based amphiphiles as efficient drug delivery vehicles.