An Improved First-Generation Synthesis ofent-Oxycodone
CHEMISTRYSELECT(2020)
摘要
An improvement in the stereoselective total synthesis of unnatural (+)-oxycodone from phenethyl acetate is described. The total step count was reduced by conducting some chemical transformations in "one-pot" and a change in the sequence of chemical operations was implemented, in comparison with the previously published first-generation synthesis. The synthesis of (+)-oxycodone was completed in a total of 12 operations (17 steps) and an overall yield of 1.6%, in comparison to our previous synthesis (13 operations, 19 steps, 1.5% yield) Experimental and spectral data are provided for all new compounds.
更多查看译文
关键词
cyclic carbonate,elimination,Heck reaction,microbial dihydroxylation,Mitsunobu reaction,oxycodone,pinacol-type coupling
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要