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The Main Directions and Recent Trends in the Synthesis and Use of Isoxazoles

Bondarenko Oksana B., Zyk Nikolai V.

Chemistry of heterocyclic compounds（2020）

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Abstract
This review summarizes the main directions and recent trends in the synthesis of isoxazoles, and also provides examples of the use of isoxazoles as biologically active compounds in medicinal chemistry. When discussing the classical methods of isoxazole synthesis, the main emphasis is placed on the problem of selectivity of transformations. Bibliography includes 112 sources.
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Key words
isoxazole,nitrile oxide,biological activity,condensation,cycloaddition,regioselectivity
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