Hypoxia-induced mitochondrial reactive oxygen species (mtROS) differentially regulates smooth muscle cell (SMC) proliferation of pulmonary and systemic vasculature

Shipra Bhansali, Kamal Sohi,Veena Dhawan

Mitochondrion（2021）

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摘要

•Hypoxia-induced mtROS differentially regulates pulmonary and systemic vascular remodeling.•Hypoxic PASMCs displayed apoptosis-resistant phenotype despite increased mtROS-induced DNA damage.•Conversely, modest mtROS levels triggered autophagy-mediated hASMC proliferation under hypoxia.

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关键词

hPASMCs,hASMCs,PAH,SAH,mtROS,AO

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